GLP-1 Dosing Guidelines: When to Increase and When to Maintain

GLP-1 medications (like Semaglutide and Tirzepetide) have quickly become some of the most effective tools for sustainable weight loss. But the key to success isn’t just starting the medication — it’s knowing how to adjust the dose safely and strategically.

At Destin Weight Loss & Wellness, we tailor dosing to each individual. Here’s a simple breakdown of how it works:

Starting Dose: Build a Foundation

Most clients begin at a low starting dose. This helps the body adjust while minimizing side effects like nausea, constipation, or fatigue. At this stage, the goal is to establish tolerance rather than push rapid weight loss.

You may not see dramatic changes right away — and that’s okay. It often takes reaching a higher, therapeutic dose before significant weight loss begins. This slow build is actually the healthiest and safest way to progress.

Increasing the Dose: When to Go Up

We typically consider a dose increase when:

• You are tolerating your current dose without significant side effects.

• Weekly weight loss has slowed below 1–2 lbs per week.

• Your appetite control isn’t as strong, and cravings return.

Our standard protocol is to increase by 5 units weekly, as needed, to keep weight loss in the safe and sustainable range of 1–2 lbs per week.

Maintenance Dose: When to Hold Steady

Not everyone needs to continue going up in dose. Some clients reach their “sweet spot” where they feel good and continue losing steadily without additional increases. We recommend staying at a maintenance dose when:

• You’re consistently losing 1–2 lbs per week.

• Your hunger and cravings are well-controlled.

• You’re feeling good with minimal side effects.

A maintenance phase helps your body stabilize and prevents unnecessary medication use or side effects.

Why Personalized Adjustments Matter

Every client’s journey is unique. Some may move up more quickly, while others stay at a lower dose and still see great results. That’s why we emphasize ongoing medical supervision, nutrition support, and lifestyle guidance.

Bottom Line:

• Start low to build tolerance.

• Increase by 5 units weekly if weight loss slows below 1–2 lbs per week.

• Expect that significant changes may begin once you reach a therapeutic dose — and that’s perfectly normal.

• Hold at maintenance when results are steady and side effects are minimal.

At Destin Weight Loss & Wellness, our team monitors your progress closely to ensure you’re on the right track. Whether you’re starting your GLP-1 journey or adjusting your current dose, we’re here to guide you every step of the way.

Book your consultation today and let’s customize a plan that works for you.